Your phosphorus levels can get too high when your kidneys aren’t working correctly. Other blood tests may be … Your health care provider will order a blood test to check your potassium level. Factors Associated With Serum Phosphate Levels in Multivariable Linear Regression. The primary outcome for this analysis was all-cause mortality. In conclusion, we found a graded independent relation between higher levels of serum phosphate and the risk of heart failure, cardiovascular events, and all-cause death in people with prior myocardial infarction, most of whom had serum phosphate levels and kidney function within the normal range. Your body regulates potassium closely in order to maintain normal function. To varying degrees, your cells, tissues and organs all depend on potassium to function normally. Higher levels of serum phosphate might identify subjects with secondary hyperparathyroidism, which has been associated with adverse cardiovascular outcomes, especially when kidney function is impaired.7,17 However, secondary hyperparathyroidism would have been unusual in CARE participants, given their relatively preserved kidney function, and primary hyperparathyroidism would be expected to reduce serum phosphate levels. Respiratory System: Respiratory difficulty. A very low potassium level can even cause your heart to stop. As with other essential minerals, however, the key to health is balance. None: I am not aware of a direct effect by phosphorous on the heart although it has inverse relationship with calcium which have strong cardiac effect Answered on … Backward and forward stepwise selection techniques obtained similar results, and variables that were significant at the P<0.2 level during backward stepwise selection were included in the final model for the relation between phosphate and all-cause death. Multivariate linear regression was used to determine factors associated with baseline serum phosphate levels. There has been considerable interest recently in the relation between increasing serum phosphate levels and adverse cardiovascular outcomes.5 However, available studies have examined the relation between phosphate and cardiovascular outcomes in prevalent subjects with impaired kidney function, many of whom had overt hyperphosphatemia and abnormal serum calcium levels resulting from secondary hyperparathyroidism.6–9 Given the biological importance of phosphorus, it is plausible that higher levels of serum phosphate may also be associated with adverse outcomes even in the absence of kidney disease and hyperphosphatemia. High phosphorus levels might also promote heart disease by triggering a hormone called parathyroid hormone, which puts the body in a state of inflammation. By continuing to browse this site you are agreeing to our use of cookies. Allergies to phosphate are rare, but it's still important to call your doctor or seek emergency care if you experience rash, hives, shortness of breath, rapid heartbeat, or swelling of the face, throat, or tongue after taking a phosphate supplement. In kidney failure, the phosphorus level can become too high. She holds a bachelor's degree in biological sciences from Goucher College and a MBA in healthcare management from the University of Baltimore. organization. Having too much phosphorus in your blood is also called hyperphosphatemia. Reinhold Erben explains that, "In patients with chronic renal disease, both the phosphate levels and … Phosphorus' mere involvement in all energy production makes it an indispensable partner to your heart since, like all organs, your heart needs energy in order to function. Some of those functions involve your heart. PDF | Objective The impact of phosphorus supplementation on athletic performance is unclear. Fully adjusted time to clinical outcomes by baseline serum phosphate. In the fully adjusted models, HRs have been adjusted for age, sex, race, baseline smoking status, diabetic status, waist-to-hip circumference ratio, baseline fasting glucose, baseline GFR, baseline hemoglobin, baseline serum albumin, baseline aspirin use, and left ventricular ejection fraction. We used Cox proportional-hazards models to examine the association between serum phosphate and adverse clinical outcomes after adjustment for potential confounders. Higher levels of serum phosphate were associated with an increased risk of new heart failure after adjustment for age, sex, and race (P for trend=0.02; Table 3) and in the model (P for trend=0.03; Table 3). High doses can lead to headaches, nausea, dizziness, diarrhea, and vomiting. Levels of 25-hydroxyvitamin D and calcitriol are reduced in heart failure, in association with increased serum phosphate but apparently normal serum calcium, after correction for serum albumin.18–20 This low vitamin D status is hypothesized to influence cardiac contractility through effects on intracellular calcium and phosphate levels20 and has been linked to a modest increase in the risk of myocardial infarction in the general population.21 Although CARE participants were free of symptomatic heart failure at baseline, we speculate that higher serum levels of phosphate might be a marker for low vitamin D status and subclinical myocardial dysfunction. the phosphorus group (142±10 beats/min) compared with placebo (135±10 beats/min). This sudden drop in phosphate level may result in an abnormal heart rhythm and even death. Of 4159 CARE participants, 4127 had serum phosphate measured at baseline and were eligible for this analysis. Health Effects: Exposure to white phosphorus may cause liver, heart, or kidney damage. Your heart and lungs are involved in transporting oxygen to your tissues and removing carbon dioxide, and problems with either of these processes affect your breathing. Learn more about its benefits here. Your body needs some phosphate, but in larger-than-normal amounts, phosphate can cause bone and muscle problems and increase your risk for heart attacks and strokes. Phosphorus supplements that contain sodium can cause edema in people with heart failure or cirrhosis. Shortness of breath that comes on suddenly (called acute) has a limited number of causes, including: Breathing white phosphorus for long periods may cause a condition known as “phossy jaw” which involves poor wound healing of the mouth and breakdown of the jaw bone. Eating or drinking small amounts of white phosphorus may cause liver, heart, or kidney damage, vomiting, stomach cramps, drowsiness, or death. This hypothesis is supported by data indicating that diet-induced reductions in serum phosphate levels lead to increased calcitriol levels in healthy men.22,23 Because no information on 25-hydroxyvitamin D or calcitriol levels was available to us, however, this hypothesis requires further study. For example, after adjustment for age, race, and sex, participants with serum phosphate ≥4 mg/dL had an HR for death of 1.42 (95% CI, 0.97 to 2.07) compared with those with serum phosphate of 2.5 to 3.4 mg/dL. The American Heart Association is qualified 501(c)(3) tax-exempt Background— Higher levels of serum phosphate are associated with adverse cardiovascular outcomes, especially in the setting of overt hyperphosphatemia. Increased blood volume makes it harder for your heart to pump blood around your body. To keep your heart healthy, the amount of salt you ingest may be restricted to 1500 mg (1.5 g) per day. 1-800-AHA-USA-1 Normal kidneys help to get rid of phosphorus. This post hoc analysis of data from a previously conducted randomized trial was approved by the institutional review board at the University of Alberta. In addition to age, race, and sex, baseline variables considered for inclusion in the multivariate model were smoking status; alcohol use; diabetic status; use of β-adrenergic blockers, thiazide diuretics, aspirin, and pravastatin; GFR; systolic and diastolic blood pressures; hemoglobin; serum calcium; serum albumin; waist-to-hip circumference ratio; body mass index; left ventricular ejection fraction; fasting serum glucose; fasting serum triglyceride; low-density lipoprotein cholesterol; high-density lipoprotein cholesterol; total cholesterol; and country of treatment (the United States or Canada). The levels of … What Vitamins Increase the Absorption of Minerals in the Body? What Is the Main Function of Phosphorus in the Body? Finally, although we did not have ionized calcium levels, simultaneous adjustment for serum calcium and albumin did not affect our results, suggesting that levels of ionized calcium are unlikely to be an important confounder of the relation between serum phosphate and clinical outcomes. These could be signs of potentially life-threatening, whole-body reaction known as anaphylaxis. It is available in a wide variety of foods, including meat, fish, dairy, and some vegetables. A second possibility is that high blood phosphorus directly causes mineral buildup in blood vessels, leading to blockage and heart problems. One of the most important organs in your body, a healthy heart helps you maintain an active lifestyle. Second, this analysis concerns a select population of individuals with prior myocardial infarction who were eligible for a randomized trial and therefore may not be representative of the general population. More importantly, all energy production and energy storage activities require phosphorus. The condition can affect the veins and arteries and is known as vascular calcification. E-mail. A raised level of FGF23 puts increased strain on the heart. However, mean kidney function was qualitatively similar in all 4 categories of baseline serum phosphate. Potassium is an essential mineral, meaning that your body must obtain it from your diet. Click here for what your phosphorus numbers should be when you have kidney disease. The heart rate increase could be attributed to a … Also, phosphorus helps regulate blood calcium, and your heart depends on calcium for proper function. Over time this can lead to increased risk of heart attack, stroke or death. It can also result in death. 142, Issue 16_suppl_2, Basic, Translational, and Clinical Research, Arteriosclerosis, Thrombosis, and Vascular Biology, Journal of the American Heart Association, Relation Between Serum Phosphate Level and Cardiovascular Event Rate in People With Coronary Disease, Arterial Calcification in Diabetes Mellitus, Association Between Serum Phosphate Levels and Stroke Risk in Patients Undergoing Hemodialysis, Fibroblast Growth Factor 23 Is an Independent and Specific Predictor of Mortality in Patients With Heart Failure and Reduced Ejection Fraction, Serum Alkaline Phosphatase Negatively Affects Endothelium-Dependent Vasodilation in Naïve Hypertensive Patients, Processed and Unprocessed Red Meat Consumption and Risk of Heart Failure, Fibroblast Growth Factor‐23 and Incident Coronary Heart Disease, Heart Failure, and Cardiovascular Mortality: The Atherosclerosis Risk In Communities Study, Alkaline Phosphatase, Serum Phosphate, and Incident Cardiovascular Disease and Total Mortality in Older Men, Serum Alkaline Phosphatase and Phosphate in Cerebral Atherosclerosis and Functional Outcomes After Cerebral Infarction, Dietary Phosphate Modulates Atherogenesis and Insulin Resistance in Apolipoprotein E Knockout Mice—Brief Report, Arterial Calcification in Chronic Kidney Disease: Key Roles for Calcium and Phosphate, Vitamin D Deficiency Is Associated With Subclinical Carotid Atherosclerosis, Conjoint Effects of Serum Calcium and Phosphate on Risk of Total, Cardiovascular, and Noncardiovascular Mortality in the Community, Dietary Phosphorus, Blood Pressure, and Incidence of Hypertension in the Atherosclerosis Risk in Communities Study and the Multi-Ethnic Study of Atherosclerosis, Fibroblast Growth Factor 23 and Left Ventricular Hypertrophy in Chronic Kidney Disease, Relation Between Alkaline Phosphatase, Serum Phosphate, and All-Cause or Cardiovascular Mortality, Global Impact of the 2017 ACC/AHA Hypertension Guidelines. Further adjustment for factors independently associated with mortality using stepwise multivariate analysis did not substantially affect the graded relation between phosphate and the risk of death (P for trend=0.03). Results were similar when individuals with baseline GFR <60 mL/min/1.73 m2 were excluded and when serum creatinine or the Cockcroft-Gault equation was used to estimate kidney function (data not shown). Treatment allocation was concealed with a centrally maintained code. 7272 Greenville Ave. Low blood phosphorus, or hypophosphatemia, can also be dangerous. © American Heart Association, Inc. All rights reserved. The relation between the baseline calcium-phosphate ion product and adverse clinical outcomes was tested by inserting a cross-product interaction term into the Cox models. Vitamin and mineral supplements rarely provide more than 15 percent of the RDA, but most foods contain phosphorus. However, the hypothesis that serum phosphate levels would be associated with adverse outcomes was formulated before the analyses were started, reducing the risk of spurious conclusions. The demographic characteristics of these remaining participants are shown in Table 1. Factors that were independently associated with serum phosphate level are shown in Table 2. In addition, laboratory measurements were made in subjects in the fasting state, which likely reduced the variability of serum phosphate levels between participants.27 Finally, outcomes were ascertained according to prespecified criteria by individuals who were unaware of serum phosphate levels. The normal amount of phosphorus in the blood (also called serum phosphorus) is between 2.5 – 4.5 mg/dL. According to Nutrition 411, blood levels of phosphorus normally range from 2.5 to 4.5 milligrams per deciliter. 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